Polypodium leucotomos, a fern native to Central and South America, has been recognized for its potent antioxidant and photoprotective properties. It is one of the best-studied dermatologic supplements with high-quality evidence supporting its use in a myriad of conditions. When taken orally, Polypodium leucotomos offers several key benefits for skin health:
Oral Polypodium leucotomos supplements are typically consumed to enhance the skin’s defense against UV damage and to provide systemic antioxidant benefits. The extract is derived from the leaves and rhizomes of the fern, and it is often available in tablet form. A novel chewable, gummy form of Polypodium extract is also available for use in pediatrics or other populations that may have trouble swallowing tablets.
Oral Polypodium leucotomos is generally considered safe for most skin types and tones. It is well-tolerated by many individuals and can be incorporated into a daily routine for enhanced sun protection and skin health. However, as with any supplement, it is advisable for individuals with specific health conditions or those taking other medications to consult with a healthcare professional before starting use.
While oral Polypodium leucotomos is usually well-tolerated, adverse reactions are exceedingly rare. However, pregnant or breastfeeding individuals should seek medical advice before use due to limited safety data in these populations. Additionally, individuals with known allergies to Polypodium leucotomos or any related compounds should avoid using products containing this ingredient to prevent adverse reactions.
Segars K, McCarver V, Miller RA. Dermatologic Applications of Polypodium leucotomos: A Literature Review. J Clin Aesthet Dermatol. 2021 Feb;14(2):50-60. Epub 2021 Feb 1.
Rodríguez-Luna A, Zamarrón A, Juarranz Á, González S. Clinical Applications of Polypodium leucotomos (Fernblock®): An Update. Life (Basel). 2023 Jul 5;13(7):1513.
Choudhry SZ, Bhatia N, Ceilley R, Hougeir F, Lieberman R, Hamzavi I, Lim HW. Role of oral Polypodium leucotomos extract in dermatologic diseases: a review of the literature. J Drugs Dermatol. 2014 Feb;13(2):148-53.
Gonzalez S, Gilaberte Y, Philips N. Mechanistic insights in the use of a Polypodium leucotomos extract as an oral and topical photoprotective agent. Photochem Photobiol Sci. 2010 Apr;9(4):559-63.
Inner Glow. Sol Defense Gummies. Inner Glow Vitamins. https://innerglowvitamins.com/products/sol-defense-gummies?variant=43087225258145. Published 2023. Accessed July 2, 2024.
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