Plant-derived nanovesicles have less allergenic potential compared with traditional exosomes. Furthermore, they are less likely to degrade compared to their animal counterparts. As a delivery mechanism, plant-derived nanovesicles have been used to deliver other antioxidant or antifungal chemicals to promote their imbibition into the skin. Grapefruit-derived nanovesicles have been shown to have a specific composition that may be useful in antineoplastic therapies.
Typically, exosomes are used by cells to package contents for cellular actions, including healing and regulation of the skin. The delivery of most products has traditionally been done from animal exosomes, but these are immunogenic, challenging to procure and unsustainable. Plant-derived nanovesicles have been used to package products in exosomes and are traditionally extracted from plants like grapefruit, aloe vera and wheat.
Plan-derived nanovesicles are likely safe for all skin types and tones. However, individuals with hypersensitivity to the plant product should avoid products containing plant-derived nanovesicles.
Available evidence does not suggest there is a major contraindication to use of products with plant-derived nanovesicles, though hypersensitivity to plant products should be considered.
Sadeghi-Ghadi Z, Vaezi A, Ahangarkani F, Ilkit M, Ebrahimnejad P, Badali H. Potent in vitro activity of curcumin and quercetin co-encapsulated in nanovesicles without hyaluronan against Aspergillus and Candida isolates. J Mycol Med. 2020;30(4):101014.
Stanly C, Alfieri M, Ambrosone A, Leone A, Fiume I, Pocsfalvi G. Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line. Cells. 2020;9(12):2722. Published 2020 Dec 21.
Tu J, Jiang F, Fang J, et al. Anticipation and Verification of Dendrobium-Derived Nanovesicles for Skin Wound Healing Targets, Predicated Upon Immune Infiltration and Senescence. Int J Nanomedicine. 2024;19:1629-1644. Published 2024 Feb 20.
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