Join the Club

MELATONIN

TYPE OF INGREDIENT​
Hormone
COMMONLY FOUND IN
Skincare products, particularly those targeting anti-aging and skin repair

WHAT ARE THE BENEFITS OF MELATONIN?

Topical melatonin, a hormone naturally produced by the body’s pineal gland, has gained attention for its potential benefits in skincare. While primarily known for regulating the sleep-wake cycle, melatonin also exhibits antioxidant and anti-inflammatory properties, making it a promising ingredient for skincare formulations.

One of the key benefits of topical melatonin is its ability to neutralize free radicals and protect the skin from oxidative stress caused by environmental factors, such as UV radiation and pollution. By scavenging free radicals, melatonin helps to prevent signs of premature aging, including fine lines, wrinkles and age spots.

Moreover, topical melatonin has been shown to support skin repair and regeneration processes, aiding in the recovery of damaged skin and promoting a healthier skin barrier. This can be particularly beneficial for individuals with compromised or aging skin, helping to improve overall skin texture and resilience.

Additionally, melatonin’s anti-inflammatory properties make it suitable for soothing irritated or sensitive skin, reducing redness, and calming inflammation.

WHAT IS MELATONIN?

Topical melatonin is a relatively new ingredient in the cosmeceutical space, and more research is needed to confirm its efficacy. However, it shows promise in the area of anti-aging therapies.

Melatonin is a hormone synthesized from the amino acid tryptophan, primarily produced by the pineal gland in the brain. Its secretion is influenced by the body’s internal clock and is typically released in response to darkness, signaling the onset of sleep. In addition to its role in circadian rhythms, melatonin acts as a potent antioxidant, helping to protect cells from oxidative damage and support various physiological processes, including skin health.

In skincare formulations, topical melatonin is typically derived from synthetic sources or plant extracts and incorporated into creams, serums, or masks designed to target specific skin concerns, such as aging, damage, or sensitivity.

IS MELATONIN SAFE FOR ALL SKIN TYPES AND TONES?

Topical melatonin is generally considered safe for most skin types, including sensitive skin, when used as directed in skincare products. Individuals with certain skin conditions or those undergoing specific dermatological treatments should consult with a healthcare professional before incorporating melatonin-based skincare products into their routine to ensure compatibility and safety.

CONTRAINDICATIONS

Although topical melatonin is generally well-tolerated, there are a few potential contraindications to consider. Pregnant or breastfeeding individuals should consult with a healthcare provider before using topical melatonin products due to limited safety data in these populations. Additionally, individuals with a history of allergic reactions or sensitivities to melatonin or any related compounds should avoid using products containing this ingredient to prevent adverse reactions.

Sources:

Rusanova I, Martínez-Ruiz L, Florido J, Rodríguez-Santana C, Guerra-Librero A, Acuña-Castroviejo D, Escames G. Protective Effects of Melatonin on the Skin: Future Perspectives. Int J Mol Sci. 2019 Oct 8;20(19):4948.

Bocheva G, Slominski RM, Janjetovic Z, Kim TK, Böhm M, Steinbrink K, Reiter RJ, Kleszczyński K, Slominski AT. Protective Role of Melatonin and Its Metabolites in Skin Aging. Int J Mol Sci. 2022 Jan 22;23(3):1238.

Greco G, Di Lorenzo R, Ricci L, Di Serio T, Vardaro E, Laneri S. Clinical Studies Using Topical Melatonin. Int J Mol Sci. 2024 May 9;25(10):5167.

Vichy Minéral 89 Moisture Recovery Night Cream

Aamir Hussain, MD, MAPP

Author

Dr. Aamir Hussain is a dermatologist currently practicing adult and pediatric dermatology in Northern Virginia. He serves on the health policy committee of the American Contact Dermatitis Society and has a clinical interest in patch testing. Dr. Hussain is an internationally-recognized speaker, writer and educator. His writings on health policy, medical education and the connections between healthcare and faith have been featured in prestigious media outlets, including The New York Times, The Washington Post, The Hill, and The Baltimore Sun. He has published numerous articles in peer-reviewed journals and is the author of several book chapters. He has presented research at major conferences, including the American Academy of Dermatology, World Congress of Dermatology, Society of Pediatric Dermatology, American Contact Dermatitis Society, American Society of Dermatopathology, Society of Investigative Dermatology and the American Society for Dermatologic Surgery.