Matrixyl
TYPE OF INGREDIENT
Anti-aging, collagen stimulator
COMMONLY FOUND IN
Serums, creams
WHAT ARE THE BENEFITS OF MATRIXYL?
Matrixyl has its most beneficial effects on skin rejuvenation through an anti-wrinkle effect, likely related to its induction of collagen in skin. This occurs in a concentration-dependent manner, which explains its inclusion in compound creams and serums. In one study of matrixyl on wound healing, the application of a matrixyl patch and cream both showed collagen stimulation in human fibroblasts; indeed, the application of a patch slightly outperformed the cream, which also had a significant improvement in wound healing.
WHAT IS MATRIXYL ?
Matrixyl (i.e., palmitoyl pentapeptide-4) is a matrikine—a messenger peptide thought to regulate extracellular matrix activity. Specifically, it is thought to influence collagen formation.
IS MATRIXYL SAFE FOR ALL SKIN TYPES AND TONES?
Matrixyl is likely safe for all skin types and tones based on available data.
CONTRAINDICATIONS
There is minimal data on contraindications for the topical application of matrixyl.
Sources:
Gomes A, Bessa LJ, Fernandes I, et al. Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities. Microbiol Spectr. 2022;10(4):e0229121.
Jones RR, Castelletto V, Connon CJ, Hamley IW. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol Pharm. 2013;10(3):1063-1069.
Kachooeian M, Mousivand Z, Sharifikolouei E, et al. Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing. ACS Omega. 2022;7(28):24695-24704. Published 2022 Jul 11.
Maquart FX, Siméon A, Pasco S, Monboisse JC. Régulation de l’activité cellulaire par la matrice extracelulaire: le concept de matrikines [Regulation of cell activity by the extracellular matrix: the concept of matrikines]. J Soc Biol. 1999;193(4-5):423-428.
Röper B, Kaisig D, Auer F, Mergen E, Molls M. Thêta-Cream versus Bepanthol lotion in breast cancer patients under radiotherapy. A new prophylactic agent in skin care?. Strahlenther Onkol. 2004;180(5):315-322.
Tałałaj U, Uścinowicz P, Bruzgo I, Surażyński A, Zaręba I, Markowska A. The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity. Molecules. 2019;24(20):3698. Published 2019 Oct 15.
Zeng Q, Jiang J, Wang J, Zhou Q, Zhang X. N-Terminal Acetylation and C-Terminal Amidation of Spirulina platensis-Derived Hexapeptide: Anti-Photoaging Activity and Proteomic Analysis. Mar Drugs. 2019;17(9):520. Published 2019 Sep 4.
