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MALASSEZIN

TYPE OF INGREDIENT​
Skin-brightening agent, melanogenesis inhibitor
COMMONLY FOUND IN
Topical treatments hyperpigmentation

WHAT ARE THE BENEFITS OF MALASSEZIN?

Malassezin is a naturally occurring indole compound produced by the skin commensal yeast Malassezia furfur. It has garnered attention for its potential in treating hyperpigmentation disorders. A proof-of-concept study published in the Journal of the American Academy of Dermatology evaluated the efficacy and safety of topical malassezin in individuals with facial hyperpigmentation. Participants applied a malassezin-containing formulation twice daily for 14 weeks, resulting in a significant reduction in epidermal melanin and clinical improvement in hyperpigmented lesions. The treatment was well-tolerated, with no reports of adverse effects. Further histopathological analysis revealed decreased epidermal melanin and reduced melanocyte dendricity after eight weeks of treatment, indicating a reversible modulation of melanogenesis without permanent alteration of melanocyte structure or function.

WHAT IS MALASSEZIN?

Malassezin is an indole derivative synthesized by Malassezia furfur, a lipophilic yeast that is part of the normal human skin microbiome. It functions as an agonist of the aryl hydrocarbon receptor (AhR) and has been shown to induce apoptosis in primary human melanocytes, leading to decreased melanin production. This mechanism suggests its potential utility as a skin-lightening agent, particularly in conditions characterized by hyperpigmentation.

IS MALASSEZIN SAFE FOR ALL SKIN TYPES AND TONES?

Current studies indicate that malassezin is well-tolerated across various skin types and tones. The absence of adverse effects in clinical evaluations suggests a favorable safety profile. However, given the limited scope of existing research, further studies are necessary to confirm its safety and efficacy across diverse populations.

CONTRAINDICATIONS

There are no specific contraindications identified for malassezin at this time. As with any new topical agent, it is advisable to conduct a patch test prior to widespread application.

Sources:

Grimes PE, Bhawan J, Howell MD, et al. “A novel proof-of-concept study assessing the lightening effects and safety of malassezin for treatment of facial hyperpigmentation.” J Am Acad Dermatol. 2022;87(2):456-458.

Grimes PE, Bhawan J, Howell MD, et al. “Histopathological Changes Induced by Malassezin: A Novel Natural Microbiome Indole for Treatment of Facial Hyperpigmentation.” J Drugs Dermatol. 2022;21(2):141-145.

Gaitanis G, Magiatis P, Hantschke M, et al. “Malassezin, a novel agonist of the aryl hydrocarbon receptor from the yeast Malassezia furfur, induces apoptosis in primary human melanocytes.” Chem Biol. 2005;12(3):287-298.

Shereen Teymour, DO

Author

Dr. Shereen Teymour is a board-certified dermatologist with expertise in medical, cosmetic, and surgical dermatology. After completing her dermatology residency at Hackensack University Medical Center, she further honed her skills in cosmetic dermatology while practicing in Beverly Hills, where she worked with a discerning clientele and developed a refined approach to aesthetic treatments. Her focus on achieving natural, personalized results quickly gained her recognition in the industry. Dr. Teymour eventually returned to New York City to join Day Dermatology & Aesthetics as a cosmetic fellow, learning alongside industry leader, Dr. Doris Day, where she continues to hone her skills and offer state-of-the-art treatments, including laser therapies, injectables, and comprehensive skincare. Known for her meticulous attention to detail and patient-centered care, Dr. Teymour is passionate about helping patients achieve optimal skin health and beauty. Beyond her clinical practice, Dr. Teymour is actively involved in the dermatology community through lectures, publications, and symposiums. She frequently speaks on advancements in cosmetic dermatology and skincare innovations. Her dedication to education, both for her patients and peers, underscores her commitment to advancing the field. Dr. Teymour’s passion for exploration, travel, and philanthropy has taken her on numerous medical missions around the world. Outside of her practice, she loves discovering new corners of New York City, connecting with people, and spending quality time with her husband and their two Shih Tzus.