As an antioxidant, madecassoside has been shown to reduce free radical damage caused by environmental stressors, such as UV rays and pollution. It also has anti-inflammatory properties. When combined with topical vitamin C, madecassoside has been shown to exhibit anti-aging properties.
Madecassoside is a compound extracted from the Centella asiatica plant. It is an ingredient commonly used in skincare products due to its ability to protect against oxidative stress and reduce inflammation.
Madecassoside is widely regarded as safe for topical application and is generally well-tolerated.
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Tan SC, Bhattamisra SK, Chellappan DK, Candasamy M. Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review. Applied Sciences. 2021; 11(18):8475.
Shen X, Guo M, Yu H, Liu D, Lu Z, Lu Y. Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica. Biosci Biotechnol Biochem. 2019 Mar;83(3):561-568.
Haftek M, Mac-Mary S, Le Bitoux MA, Creidi P, Seité S, Rougier A, Humbert P. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp Dermatol. 2008 Nov;17(11):946-52.
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