Coenzyme Q10 (CoQ10) in skin care products helps repair skin damage and promote overall skin health. It protects the skin against free radicals in the environment that degrade collagen and contribute to skin aging. CoQ10 is also used in skincare products to prevent and treat hyperpigmentation as it blocks tyrosinase, the enzyme that leads to melanin production. Clinical studies have shown improvement in skin wrinkles and smoothness following ingestion of CoQ10 supplements as well.
Coenzyme Q10, also known as ubiquinone, is an antioxidant that is naturally found in the body. Antioxidants help protect against skin aging by neutralizing free radicals in the environment, such as those caused by UV radiation and pollution.
CoQ10 in skincare is generally well-tolerated.
CoQ10 supplements appear to be safe and well-tolerated. Mild side effects include digestive problems, such as abdominal pain and decreased appetite.
Knott A, Achterberg V, Smuda C, et al. Topical treatment with coenzyme Q10-containing formulas improves skin’s Q10 level and provides antioxidative effects. Biofactors. 2015;41(6):383-390.
Hseu YC, Ho YG, Mathew DC, Yen HR, Chen XZ, Yang HL. The in vitro and in vivo depigmenting activity of coenzyme Q10 through the down-regulation of α-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes. Biochem Pharmacol. 2019;164:299-310.
Žmitek K, Pogačnik T, Mervic L, Žmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. Biofactors. 2017 Jan 2;43(1):132-140.
©2025 Club Derm. All Rights Reserved